Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.
Identifieur interne : 000412 ( Main/Exploration ); précédent : 000411; suivant : 000413Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.
Auteurs : Robert L. Coleman [États-Unis] ; Amit M. Oza [Canada] ; Domenica Lorusso [Italie] ; Carol Aghajanian [États-Unis] ; Ana Oaknin [Espagne] ; Andrew Dean [Australie] ; Nicoletta Colombo [Italie] ; Johanne I. Weberpals [Canada] ; Andrew Clamp [Royaume-Uni] ; Giovanni Scambia [Italie] ; Alexandra Leary [France] ; Robert W. Holloway [États-Unis] ; Margarita Amenedo Gancedo [Espagne] ; Peter C. Fong [Nouvelle-Zélande] ; Jeffrey C. Goh [Australie] ; David M. O'Malley [États-Unis] ; Deborah K. Armstrong [États-Unis] ; Jesus Garcia-Donas [Espagne] ; Elizabeth M. Swisher [États-Unis] ; Anne Floquet [France] ; Gottfried E. Konecny [États-Unis] ; Iain A. Mcneish [Royaume-Uni] ; Clare L. Scott [Australie] ; Terri Cameron [États-Unis] ; Lara Maloney [États-Unis] ; Jeff Isaacson [États-Unis] ; Sandra Goble [États-Unis] ; Caroline Grace [États-Unis] ; Thomas C. Harding [États-Unis] ; Mitch Raponi [États-Unis] ; James Sun [États-Unis] ; Kevin K. Lin [États-Unis] ; Heidi Giordano [États-Unis] ; Jonathan A. Ledermann [Royaume-Uni]Source :
- Lancet (London, England) [ 1474-547X ] ; 2017.
Abstract
Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity. In this trial we assessed rucaparib versus placebo after response to second-line or later platinum-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma.
DOI: 10.1016/S0140-6736(17)32440-6
PubMed: 28916367
Affiliations:
- Australie, Canada, Espagne, France, Italie, Nouvelle-Zélande, Royaume-Uni, États-Unis
- Angleterre, Aquitaine, Californie, Catalogne, Colorado, Communauté de Madrid, Floride, Grand Londres, Grand Manchester, Latium, Lombardie, Maryland, Massachusetts, Nouvelle-Aquitaine, Ohio, Texas, Washington (État), Écosse, État de New York
- Barcelone, Bordeaux, Glasgow, Londres, Madrid, Manchester, Milan, Rome, Seattle
- Université de Glasgow, Université de Manchester, Université de Washington
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Swisher</name><affiliation wicri:level="4"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Floquet, Anne" sort="Floquet, Anne" uniqKey="Floquet A" first="Anne" last="Floquet">Anne Floquet</name><affiliation wicri:level="3"><nlm:affiliation>Groupe d'Investigateurs Nationaux pour l'Étude des Cancers Ovariens et du sein and Institut Bergonié, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Groupe d'Investigateurs Nationaux pour l'Étude des Cancers Ovariens et du sein and Institut Bergonié, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Konecny, Gottfried E" sort="Konecny, Gottfried E" uniqKey="Konecny G" first="Gottfried E" last="Konecny">Gottfried E. 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Mcneish</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Scott, Clare L" sort="Scott, Clare L" uniqKey="Scott C" first="Clare L" last="Scott">Clare L. 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Harding</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Sun, James" sort="Sun, James" uniqKey="Sun J" first="James" last="Sun">James Sun</name><affiliation wicri:level="2"><nlm:affiliation>Foundation Medicine, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Foundation Medicine, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lin, Kevin K" sort="Lin, Kevin K" uniqKey="Lin K" first="Kevin K" last="Lin">Kevin K. Lin</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Giordano, Heidi" sort="Giordano, Heidi" uniqKey="Giordano H" first="Heidi" last="Giordano">Heidi Giordano</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Ledermann, Jonathan A" sort="Ledermann, Jonathan A" uniqKey="Ledermann J" first="Jonathan A" last="Ledermann">Jonathan A. Ledermann</name><affiliation wicri:level="3"><nlm:affiliation>University College London Cancer Institute and University College London Hospitals, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London Cancer Institute and University College London Hospitals, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28916367</idno><idno type="pmid">28916367</idno><idno type="doi">10.1016/S0140-6736(17)32440-6</idno><idno type="wicri:Area/PubMed/Corpus">000403</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000403</idno><idno type="wicri:Area/PubMed/Curation">000401</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000401</idno><idno type="wicri:Area/PubMed/Checkpoint">000401</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000401</idno><idno type="wicri:Area/Ncbi/Merge">004E70</idno><idno type="wicri:Area/Ncbi/Curation">004E70</idno><idno type="wicri:Area/Ncbi/Checkpoint">004E70</idno><idno type="wicri:Area/Main/Merge">000407</idno><idno type="wicri:Area/Main/Curation">000412</idno><idno type="wicri:Area/Main/Exploration">000412</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.</title><author><name sortKey="Coleman, Robert L" sort="Coleman, Robert L" uniqKey="Coleman R" first="Robert L" last="Coleman">Robert L. Coleman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: rcoleman@mdanderson.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Oza, Amit M" sort="Oza, Amit M" uniqKey="Oza A" first="Amit M" last="Oza">Amit M. Oza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Princess Margaret Cancer Centre, University Health Network, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Lorusso, Domenica" sort="Lorusso, Domenica" uniqKey="Lorusso D" first="Domenica" last="Lorusso">Domenica Lorusso</name><affiliation wicri:level="3"><nlm:affiliation>Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies and Gynecologic Oncology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies and Gynecologic Oncology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Aghajanian, Carol" sort="Aghajanian, Carol" uniqKey="Aghajanian C" first="Carol" last="Aghajanian">Carol Aghajanian</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Oaknin, Ana" sort="Oaknin, Ana" uniqKey="Oaknin A" first="Ana" last="Oaknin">Ana Oaknin</name><affiliation wicri:level="3"><nlm:affiliation>Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Dean, Andrew" sort="Dean, Andrew" uniqKey="Dean A" first="Andrew" last="Dean">Andrew Dean</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, St John of God Subiaco Hospital, Subiaco, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Oncology, St John of God Subiaco Hospital, Subiaco, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Colombo, Nicoletta" sort="Colombo, Nicoletta" uniqKey="Colombo N" first="Nicoletta" last="Colombo">Nicoletta Colombo</name><affiliation wicri:level="3"><nlm:affiliation>Gynecologic Cancer Program, European Institute of Oncology and University of Milan-Bicocca, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Gynecologic Cancer Program, European Institute of Oncology and University of Milan-Bicocca, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Weberpals, Johanne I" sort="Weberpals, Johanne I" uniqKey="Weberpals J" first="Johanne I" last="Weberpals">Johanne I. Weberpals</name><affiliation wicri:level="1"><nlm:affiliation>Ottawa Hospital Research Institute, Ottawa, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Ottawa Hospital Research Institute, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Clamp, Andrew" sort="Clamp, Andrew" uniqKey="Clamp A" first="Andrew" last="Clamp">Andrew Clamp</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Oncology, Christie National Health Service Foundation Trust and University of Manchester, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical Oncology, Christie National Health Service Foundation Trust and University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Scambia, Giovanni" sort="Scambia, Giovanni" uniqKey="Scambia G" first="Giovanni" last="Scambia">Giovanni Scambia</name><affiliation wicri:level="3"><nlm:affiliation>Gynecologic Oncology, Università Cattolica Roma, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Gynecologic Oncology, Università Cattolica Roma, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Leary, Alexandra" sort="Leary, Alexandra" uniqKey="Leary A" first="Alexandra" last="Leary">Alexandra Leary</name><affiliation wicri:level="1"><nlm:affiliation>Group d'Investigateurs Nationaux pour l'Étude des Cancers Ovariens et du sein and Gynecological Unit, Department of Medicine, Gustave Roussy Cancer Center and Institut National de la Santé et de la Recherche Médicale U981, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Group d'Investigateurs Nationaux pour l'Étude des Cancers Ovariens et du sein and Gynecological Unit, Department of Medicine, Gustave Roussy Cancer Center and Institut National de la Santé et de la Recherche Médicale U981, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Holloway, Robert W" sort="Holloway, Robert W" uniqKey="Holloway R" first="Robert W" last="Holloway">Robert W. Holloway</name><affiliation wicri:level="2"><nlm:affiliation>Department of Gynecologic Oncology, Florida Hospital Cancer Institute, Orlando, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gynecologic Oncology, Florida Hospital Cancer Institute, Orlando, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Gancedo, Margarita Amenedo" sort="Gancedo, Margarita Amenedo" uniqKey="Gancedo M" first="Margarita Amenedo" last="Gancedo">Margarita Amenedo Gancedo</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, Oncology Center of Galicia, La Coruña, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Medical Oncology Department, Oncology Center of Galicia, La Coruña</wicri:regionArea><wicri:noRegion>La Coruña</wicri:noRegion></affiliation></author><author><name sortKey="Fong, Peter C" sort="Fong, Peter C" uniqKey="Fong P" first="Peter C" last="Fong">Peter C. Fong</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, Auckland City Hospital, Grafton, Auckland, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Medical Oncology Department, Auckland City Hospital, Grafton, Auckland</wicri:regionArea><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Goh, Jeffrey C" sort="Goh, Jeffrey C" uniqKey="Goh J" first="Jeffrey C" last="Goh">Jeffrey C. Goh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Oncology, Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="O Malley, David M" sort="O Malley, David M" uniqKey="O Malley D" first="David M" last="O'Malley">David M. O'Malley</name><affiliation wicri:level="2"><nlm:affiliation>Gynecologic Oncology, Ohio State University, James Cancer Center, Columbus, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gynecologic Oncology, Ohio State University, James Cancer Center, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Armstrong, Deborah K" sort="Armstrong, Deborah K" uniqKey="Armstrong D" first="Deborah K" last="Armstrong">Deborah K. Armstrong</name><affiliation wicri:level="2"><nlm:affiliation>Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Garcia Donas, Jesus" sort="Garcia Donas, Jesus" uniqKey="Garcia Donas J" first="Jesus" last="Garcia-Donas">Jesus Garcia-Donas</name><affiliation wicri:level="3"><nlm:affiliation>HM Hospitales-Centro Integral Oncológico Hospital de Madrid Clara Campal, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>HM Hospitales-Centro Integral Oncológico Hospital de Madrid Clara Campal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Swisher, Elizabeth M" sort="Swisher, Elizabeth M" uniqKey="Swisher E" first="Elizabeth M" last="Swisher">Elizabeth M. Swisher</name><affiliation wicri:level="4"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Floquet, Anne" sort="Floquet, Anne" uniqKey="Floquet A" first="Anne" last="Floquet">Anne Floquet</name><affiliation wicri:level="3"><nlm:affiliation>Groupe d'Investigateurs Nationaux pour l'Étude des Cancers Ovariens et du sein and Institut Bergonié, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Groupe d'Investigateurs Nationaux pour l'Étude des Cancers Ovariens et du sein and Institut Bergonié, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Konecny, Gottfried E" sort="Konecny, Gottfried E" uniqKey="Konecny G" first="Gottfried E" last="Konecny">Gottfried E. Konecny</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of California, Los Angeles, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mcneish, Iain A" sort="Mcneish, Iain A" uniqKey="Mcneish I" first="Iain A" last="Mcneish">Iain A. Mcneish</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Scott, Clare L" sort="Scott, Clare L" uniqKey="Scott C" first="Clare L" last="Scott">Clare L. Scott</name><affiliation wicri:level="1"><nlm:affiliation>Royal Melbourne Hospital, Parkville, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Melbourne Hospital, Parkville, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Cameron, Terri" sort="Cameron, Terri" uniqKey="Cameron T" first="Terri" last="Cameron">Terri Cameron</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Maloney, Lara" sort="Maloney, Lara" uniqKey="Maloney L" first="Lara" last="Maloney">Lara Maloney</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Isaacson, Jeff" sort="Isaacson, Jeff" uniqKey="Isaacson J" first="Jeff" last="Isaacson">Jeff Isaacson</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Goble, Sandra" sort="Goble, Sandra" uniqKey="Goble S" first="Sandra" last="Goble">Sandra Goble</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Grace, Caroline" sort="Grace, Caroline" uniqKey="Grace C" first="Caroline" last="Grace">Caroline Grace</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Harding, Thomas C" sort="Harding, Thomas C" uniqKey="Harding T" first="Thomas C" last="Harding">Thomas C. Harding</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Sun, James" sort="Sun, James" uniqKey="Sun J" first="James" last="Sun">James Sun</name><affiliation wicri:level="2"><nlm:affiliation>Foundation Medicine, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Foundation Medicine, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lin, Kevin K" sort="Lin, Kevin K" uniqKey="Lin K" first="Kevin K" last="Lin">Kevin K. Lin</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Giordano, Heidi" sort="Giordano, Heidi" uniqKey="Giordano H" first="Heidi" last="Giordano">Heidi Giordano</name><affiliation wicri:level="2"><nlm:affiliation>Clovis Oncology, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clovis Oncology, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Ledermann, Jonathan A" sort="Ledermann, Jonathan A" uniqKey="Ledermann J" first="Jonathan A" last="Ledermann">Jonathan A. Ledermann</name><affiliation wicri:level="3"><nlm:affiliation>University College London Cancer Institute and University College London Hospitals, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London Cancer Institute and University College London Hospitals, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity. In this trial we assessed rucaparib versus placebo after response to second-line or later platinum-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Nouvelle-Zélande</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Californie</li><li>Catalogne</li><li>Colorado</li><li>Communauté de Madrid</li><li>Floride</li><li>Grand Londres</li><li>Grand Manchester</li><li>Latium</li><li>Lombardie</li><li>Maryland</li><li>Massachusetts</li><li>Nouvelle-Aquitaine</li><li>Ohio</li><li>Texas</li><li>Washington (État)</li><li>Écosse</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Bordeaux</li><li>Glasgow</li><li>Londres</li><li>Madrid</li><li>Manchester</li><li>Milan</li><li>Rome</li><li>Seattle</li></settlement><orgName><li>Université de Glasgow</li><li>Université de Manchester</li><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Coleman, Robert L" sort="Coleman, Robert L" uniqKey="Coleman R" first="Robert L" last="Coleman">Robert L. Coleman</name></region><name sortKey="Aghajanian, Carol" sort="Aghajanian, Carol" uniqKey="Aghajanian C" first="Carol" last="Aghajanian">Carol Aghajanian</name><name sortKey="Armstrong, Deborah K" sort="Armstrong, Deborah K" uniqKey="Armstrong D" first="Deborah K" last="Armstrong">Deborah K. Armstrong</name><name sortKey="Cameron, Terri" sort="Cameron, Terri" uniqKey="Cameron T" first="Terri" last="Cameron">Terri Cameron</name><name sortKey="Giordano, Heidi" sort="Giordano, Heidi" uniqKey="Giordano H" first="Heidi" last="Giordano">Heidi Giordano</name><name sortKey="Goble, Sandra" sort="Goble, Sandra" uniqKey="Goble S" first="Sandra" last="Goble">Sandra Goble</name><name sortKey="Grace, Caroline" sort="Grace, Caroline" uniqKey="Grace C" first="Caroline" last="Grace">Caroline Grace</name><name sortKey="Harding, Thomas C" sort="Harding, Thomas C" uniqKey="Harding T" first="Thomas C" last="Harding">Thomas C. Harding</name><name sortKey="Holloway, Robert W" sort="Holloway, Robert W" uniqKey="Holloway R" first="Robert W" last="Holloway">Robert W. Holloway</name><name sortKey="Isaacson, Jeff" sort="Isaacson, Jeff" uniqKey="Isaacson J" first="Jeff" last="Isaacson">Jeff Isaacson</name><name sortKey="Konecny, Gottfried E" sort="Konecny, Gottfried E" uniqKey="Konecny G" first="Gottfried E" last="Konecny">Gottfried E. Konecny</name><name sortKey="Lin, Kevin K" sort="Lin, Kevin K" uniqKey="Lin K" first="Kevin K" last="Lin">Kevin K. Lin</name><name sortKey="Maloney, Lara" sort="Maloney, Lara" uniqKey="Maloney L" first="Lara" last="Maloney">Lara Maloney</name><name sortKey="O Malley, David M" sort="O Malley, David M" uniqKey="O Malley D" first="David M" last="O'Malley">David M. O'Malley</name><name sortKey="Raponi, Mitch" sort="Raponi, Mitch" uniqKey="Raponi M" first="Mitch" last="Raponi">Mitch Raponi</name><name sortKey="Sun, James" sort="Sun, James" uniqKey="Sun J" first="James" last="Sun">James Sun</name><name sortKey="Swisher, Elizabeth M" sort="Swisher, Elizabeth M" uniqKey="Swisher E" first="Elizabeth M" last="Swisher">Elizabeth M. Swisher</name></country><country name="Canada"><noRegion><name sortKey="Oza, Amit M" sort="Oza, Amit M" uniqKey="Oza A" first="Amit M" last="Oza">Amit M. Oza</name></noRegion><name sortKey="Weberpals, Johanne I" sort="Weberpals, Johanne I" uniqKey="Weberpals J" first="Johanne I" last="Weberpals">Johanne I. Weberpals</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Lorusso, Domenica" sort="Lorusso, Domenica" uniqKey="Lorusso D" first="Domenica" last="Lorusso">Domenica Lorusso</name></region><name sortKey="Colombo, Nicoletta" sort="Colombo, Nicoletta" uniqKey="Colombo N" first="Nicoletta" last="Colombo">Nicoletta Colombo</name><name sortKey="Scambia, Giovanni" sort="Scambia, Giovanni" uniqKey="Scambia G" first="Giovanni" last="Scambia">Giovanni Scambia</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Oaknin, Ana" sort="Oaknin, Ana" uniqKey="Oaknin A" first="Ana" last="Oaknin">Ana Oaknin</name></region><name sortKey="Gancedo, Margarita Amenedo" sort="Gancedo, Margarita Amenedo" uniqKey="Gancedo M" first="Margarita Amenedo" last="Gancedo">Margarita Amenedo Gancedo</name><name sortKey="Garcia Donas, Jesus" sort="Garcia Donas, Jesus" uniqKey="Garcia Donas J" first="Jesus" last="Garcia-Donas">Jesus Garcia-Donas</name></country><country name="Australie"><noRegion><name sortKey="Dean, Andrew" sort="Dean, Andrew" uniqKey="Dean A" first="Andrew" last="Dean">Andrew Dean</name></noRegion><name sortKey="Goh, Jeffrey C" sort="Goh, Jeffrey C" uniqKey="Goh J" first="Jeffrey C" last="Goh">Jeffrey C. Goh</name><name sortKey="Scott, Clare L" sort="Scott, Clare L" uniqKey="Scott C" first="Clare L" last="Scott">Clare L. Scott</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Clamp, Andrew" sort="Clamp, Andrew" uniqKey="Clamp A" first="Andrew" last="Clamp">Andrew Clamp</name></region><name sortKey="Ledermann, Jonathan A" sort="Ledermann, Jonathan A" uniqKey="Ledermann J" first="Jonathan A" last="Ledermann">Jonathan A. Ledermann</name><name sortKey="Mcneish, Iain A" sort="Mcneish, Iain A" uniqKey="Mcneish I" first="Iain A" last="Mcneish">Iain A. Mcneish</name></country><country name="France"><noRegion><name sortKey="Leary, Alexandra" sort="Leary, Alexandra" uniqKey="Leary A" first="Alexandra" last="Leary">Alexandra Leary</name></noRegion><name sortKey="Floquet, Anne" sort="Floquet, Anne" uniqKey="Floquet A" first="Anne" last="Floquet">Anne Floquet</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Fong, Peter C" sort="Fong, Peter C" uniqKey="Fong P" first="Peter C" last="Fong">Peter C. Fong</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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